Noninvasive high frequency oscillatory ventilation versus Noninvasive intermittent positive pressure ventilation as a primary respiratory support in preterms with respiratory distress syndrome- A Randomized Control Trial

Invasive ventilation (IV) is a key procedure to reduce respiratory  mortality and morbidity in preterm infants with  respiratory distress syndrome (RDS). However, it is associated with the increased risks of bronchopulmonary dysplasia (BPD) ,re-hospitalization, and brain injury among the survivors .Nasal high-frequency oscillatory ventilation (NHFOV) appears to combine the advantages of continuous distending pressure and non-invasive ventilation without need for synchronization  and may reduce the incidence of intubation in preterm infants with RDS. A multicentre study has indicated that NHFOV is related to the reducednumbers of apnea, bradycardia, and oxygen desaturation as a remedial measure after failing other noninvasive modes in preterm infants. Hence the purpose of this study is to compare efficacy of noninvasive high frequency ventilation versus non invasive intermittent positive pressure ventilation in preterms with respiratory distress syndrome.