Influence of ingestion of eicosapentaenoic acid-rich fish oil on muscle damage and delayed onset muscle soreness following eccentric contractions: a randomized, double-blind, placebo-controlled, parallel-group trial
- Conditions
- muscle damage and delayed onset muscle soreness
- Registration Number
- JPRN-UMIN000018285
- Lead Sponsor
- Okayama University
- Brief Summary
Compared with the control group, M-wave latency was significantly shorter in the fish oil group immediately after exercise (p = 0.040), MVC torque was significantly higher at 1 day after exercise (p = 0.049), ROM was significantly greater at post and 2 days after exercise (post; p = 0.006, day 2; p = 0.014), and there was significantly less delayed onset muscle soreness at 1 and 2 days after exercise (day 1; p = 0.049, day 2; p = 0.023).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- Male
- Target Recruitment
- 21
Not provided
Subjects with /regular resistance training /no exercise /serious liver, kidney, heart, respiratory, endocrine or metabolic diseases/ scheduled for surgery during this study/ administration of regular medication / food allergies to fish/ participation of other clinical trial during this study/ restriction of exercise/ any reason in the opinion of the lead principal investigator not to take part in this study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. After ingestion of tested materials for 8 weeks, subjects perform eccentric contraction (ECC) with elbow flexors. During ECC, 1) electromyogram 2) isotonic contraction torque 2. After ingestion of tested materials for 8 weeks, subjects perform eccentric contraction (ECC) with elbow flexors. Before and after ECC, 1) ultrasonic imaging analysis for elbow flexors 2) reactivity of electrical micro-stimulation 3) maximal isometric contraction torque 4) range of motion 5)muscle soreness measured as a visual analog scale 6)muscle soreness measured by algesiometer
- Secondary Outcome Measures
Name Time Method 1. After ingestion of tested materials for 8 weeks, subjects perform eccentric contraction (ECC) with elbow flexors. During ECC, analyzing ultrasonic imaging for elbow flexors. 2. After ingestion of tested materials for 8 weeks, subjects perform eccentric contraction (ECC) with elbow flexors. Before and after ECC, testing blood makers (creatine kinase, myoglobin, IL-6, TNF-alpha).