Ghrelin Levels in Patients With Protein C Deficiency

• Conditions: Protein C Deficiency
• Interventions: Genetic: Protein C deficiency

• Registration Number: NCT04180657
• Lead Sponsor: University of Aarhus

Brief Summary

In rodents with protein C deficiency elevated levels of ghrelin has been observed. The purpose of this study is to investigate if patients with protein C deficiency also have elevated levels of ghrelin, and if so, how this affects the patients.

30 patients with protein C deficiency and 30 healthy BMI and gender matched controls are recruited. Bloodsamples are taken in order to measure ghrelin and GH levels and other metabolic parameters. The patients and controls are also asked to answer a questionaire regarding appetite.

If patients with protein C deficiency have higher levels of ghrelin than the general population, this will lead to new studies that will perhaps help us understand the importance of ghrelin in humans.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design

Study Timeline

• Status Verified: 2019-10
• Study First Submitted: 2019-10-21
• Study First Submitted QC: 2019-11-25
• Last Update Submitted: 2019-11-25
• Study First Posted: 2019-11-27
• Last Update Posted: 2019-11-27
• Study Start: 2020-01
• Primary Completion: 2020-04
• Study Completion: 2020-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• protein C deficiency or healthy subjects
• age 18-70
• BMI 18-35
• written statement to join the study

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Exclusion Criteria

• chronic illness, apart from protein C deficiency and lifestyle diseases
• everyday medication apart from statins, oral diabetes medication and antihypertensive drugs.
• blood donation within three months prior to the investigation.
• Alcohol abuse

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients with protein C deficiency	Protein C deficiency	Patient and control group are compared regarding ghrelin, growth hormone levels and appetite, and no other intervention is made.

Primary Outcome Measures

Name	Time	Method
acyl ghrelin and des acyl ghrelin measured in mg/dl	6 month

Secondary Outcome Measures

Name	Time	Method
Growth hormone measured in pmol/L	6 month