Ghrelin Levels in Patients With Protein C Deficiency
- Conditions
- Protein C Deficiency
- Registration Number
- NCT04180657
- Lead Sponsor
- University of Aarhus
- Brief Summary
In rodents with protein C deficiency elevated levels of ghrelin has been observed. The purpose of this study is to investigate if patients with protein C deficiency also have elevated levels of ghrelin, and if so, how this affects the patients.
30 patients with protein C deficiency and 30 healthy BMI and gender matched controls are recruited. Bloodsamples are taken in order to measure ghrelin and GH levels and other metabolic parameters. The patients and controls are also asked to answer a questionaire regarding appetite.
If patients with protein C deficiency have higher levels of ghrelin than the general population, this will lead to new studies that will perhaps help us understand the importance of ghrelin in humans.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 60
- protein C deficiency or healthy subjects
- age 18-70
- BMI 18-35
- written statement to join the study
- chronic illness, apart from protein C deficiency and lifestyle diseases
- everyday medication apart from statins, oral diabetes medication and antihypertensive drugs.
- blood donation within three months prior to the investigation.
- Alcohol abuse
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method acyl ghrelin and des acyl ghrelin measured in mg/dl 6 month
- Secondary Outcome Measures
Name Time Method Growth hormone measured in pmol/L 6 month
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