Examination of the Effect of Nd:YAG Laser on Oxidative Stress and Matrix Metalloproteinase-9 in Teeth With Apical Periodontitis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 58
- 试验地点
- 1
- 主要终点
- Measurement of TOS, TAOC and MMP-9 levels in periapical exudate and GCF
研究概览
简要总结
The objective of this clinical investigation is to examine the impact of Nd:YAG laser therapy on oxidative stress and matrix metalloproteinase-9 (MMP-9) levels in teeth afflicted with apical periodontitis. Samples were collected from patients who had undergone treatment with the Nd:YAG laser and compared with samples collected from patients who had not received this treatment. The study commenced with a sample of 60 patients. However, the study was completed with 58 patients. The study concluded with the following finding: the use of Nd:YAG lasers was not found to be superior.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 25 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients aged between 25 and 50 years and classified as American Society of Anesthesiologists (ASA) I. The maxillar and mandibular incisors and premolars with chronic apical periodontitis of a PAI score of 3 or 4 were included.
排除标准
- •Patients with American Society of Anesthesiologists (ASA) classification II or higher, pregnant, patients with localised or generalised periodontitis, patients who had used antibiotics in the last month and anti-inflammatory drugs in the last week, smokers, and teeth with internal or external root resorption, swelling, palpation pain or fistula in the relevant area, root fracture or incomplete root formation, and teeth that could not be isolated with rubber dam were not included in the study.
结局指标
主要结局
Measurement of TOS, TAOC and MMP-9 levels in periapical exudate and GCF
时间窗: The initial and seventh days of the treatment period
TOS, TAOC and MMP-9 levels were measured by ELISA in periapical exudate and GCF samples collected during routine root canal treatment in patients with apical periodontitis. No significant difference was detected in the change in biomarker levels between the group treated with the Nd:YAG laser and the control group.
次要结局
- Determination of the correlation relationship between TOS, TAOC and MMP-9 levels in periapical exudate and GCF samples(The initial and seventh days of the treatment period)
研究者
Ali Turkyilmaz
Associate Professor
Kırıkkale University