Susceptibility to respiratory tract infections
- Conditions
- ATEMWEGSINFEKTANFLLIGKEITJ00J01J02J03J04J05J06J12J13
- Registration Number
- DRKS00003381
- Lead Sponsor
- niversitätsklinikum Freiburg
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 1500
Screening study (step 1)
20-70 years of age
- comprehension of German language
- resident of Freiburg and Breisgau/Hochschwarzwald
- consent for participation in questionnaire study.
Supplementary study (step 2):
same as above
- lack of indicated co-morbidities
- consent for participation in supplementary study including consent to 1) provide a saliva samples as source of genomic DNA, 2) to allow study nurse to contact participant and primary care physician to validate phenotype
- highest 7.5% of RTI score (group 1)
- lowest 40% RTI score (group 2).
Screening study:
- Residence outside study region
- non-comprehension of German language
- lack of consent
Supplementary study:
same as above
- prevalence of indicated co-morbidities
- lack of consent for supplementary study
- RTI score outside range of interest
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To determine the proportion and characteristics of individuals in Germany with frequent and/or severe RTI of unknown cause.
- Secondary Outcome Measures
Name Time Method To identify genetic susceptibility biomarkers for this phenotype for subsequent prospective validation in independent study populations.
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.