Combination of Remifentanil and Flurbiprofen in Sedation and Analgesia for ESWL of Pancreatic Stone
Trial Snapshot
- Phase
- Phase 4
- Status
- Completed
- Sponsor
- Changhai Hospital
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Visual analogue score of pain
Study Overview
Brief Summary
Extracorporeal shock wave lithotripsy (ESWL) of pancreatic stones has been described as an effective approach for stone drainage and pain relief, and general or epidural anesthesia has been reported for such procedure. Single infusion of remifentanil has been described in ESWL of urinary stones, but it has never been described in ESWL of pancreatic stones. Moreover, single infusion of remifentanil might induce several complications, such as postoperative nausea and vomiting. The investigators attended to investigated whether combination of flurbiprofen with remifentanil reduced remifentanil dose and attenuated the complications.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •aged 18-65 years
- •ESWL indication was met
Exclusion Criteria
- •patients with hypertension
- •patients compromised in cardiopulmonary function
- •patients undergoing ESWL for the second or more times
Arms & Interventions
Flur group
Patients in this group receive both infusion of flurbiprofen and remifentanil
Intervention: Flurbiprofen and remifentanil (Drug)
Rem group
Patients in this group receive single infusion of remifentanil with target concentration infusion.
Intervention: Remifentanil (Drug)
Outcomes
Primary Outcomes
Visual analogue score of pain
Time Frame: During ESWL procedure
Secondary Outcomes
- Cardiovascular responses including blood pressure and heart rate(During ESWL procedure)
Investigators
Jia-feng Wang
M.D.
Changhai Hospital