The Risk of Uncomplicated Peptic Ulcer in a Cohort of Secondary Prevention Aspirin Users
- Conditions
- Uncomplicated Peptic Ulcer
- Registration Number
- NCT01814943
- Lead Sponsor
- AstraZeneca
- Brief Summary
This study is conducted in a cohort of low dose aspirin (ASA) users previously ascertained. The aims of the post hoc analyses are:
To estimate the incidence of uncomplicated peptic ulcer (UPU) in a cohort of low-dose ASA for secondary prevention of vascular disease and the relative risk of UPU associated with use and discontinuation of use of low dose ASA.
To estimate the effect of proton pump inhibitors (PPI) on the occurrence of UPU among users of low-dose ASA for secondary prevention of vascular disease To evaluate the effect of other risk factors on the occurrence of UPU among users of low-dose ASA for secondary prevention of vascular disease.
- Detailed Description
The risk of uncomplicated peptic ulcer in a cohort of secondary prevention aspirin users
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 39000
- Patients aged 50-84 years in 2000-2007 with a first prescription of low dose ASA ( see study population description)
- Patients aged below age 50 and 85 years and above ( see study population description)
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Incidence rates of uncomplicated peptic ulcer in a cohort of secondary prevention aspirin users From 1 January 2000 till 30 September 2011, an expected average of 6 years. Risk (hazard ratio) of developing uncomplicated peptic ulcer in a cohort of secondary prevention aspirin users From 1 Januart 2000 till 30 September 2011, an expected average of 6 years
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Research Site
🇪🇸Madrid, Spain