Quantitative and qualitative analysis of T cells infiltrating the skin of children suffering from graft-versus-host disease

Completed

• Conditions: transplantatieziekte (GvHD); Graft-versus-Host Disease; GvHD

• Registration Number: NL-OMON37587
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

Pediatric patients after HSCT that have developed/are suspected of GvHD for which the physician wants to take a skin biopsy.

Exclusion Criteria

Not-pediatric, patients (or legal representatives) not willing to undergo biopsy, contra-indications for skin biopsy (allergic for topical anesthetics).

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Number, phenotype and specificity of the T cells when comparing the several<br /><br>subgroups.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Grade of GvHD, therapy-response.</p><br>