Programming by Estrogen Treatment in Gonadotropin Releasing Hormone Antagonist Protocol
Overview
- Phase
- Phase 4
- Intervention
- estradiol valerate
- Conditions
- Infertility
- Sponsor
- Meir Medical Center
- Enrollment
- 63
- Locations
- 1
- Primary Endpoint
- ovum pickup rate that took place between Sunday to Thursday without a compromise
- Status
- Completed
- Last Updated
- 12 years ago
Overview
Brief Summary
The purpose of this study is to determine if pretreatment with Estrogen can assist in the planning and programming of In Vitro Fertilization treatments.
Detailed Description
A randomised controlled trial in which study group will be given estrogen derivative before ovarian stimulation in GnRH antagonist protocol and compared to the classical GnRH agonist protocol.Estrogen will be given P.O , "PROGYNOVA' , in a dose of 2 mg /d, starting day 2 of menses and until first Monday to follow. Main outcome measure will be ability to control the ovum pickup day, calculated as a rate of ideal pickups divided by the entire pickup number. All women enrolled will be under 38 years of age, with a clear indication for IVF other than ovulatory dysfunction. women with past 4 treatment failures will be excluded as well as cases in which sperm achieved in surgical methods.
Investigators
Eligibility Criteria
Inclusion Criteria
- •IVF treatment in the following indications: Male, Mechanical, Unexplained
- •Age\<38 years
- •Treatment Cycle number 1-4
Exclusion Criteria
- •Ovulatory disorder as an indication for IVF
- •Repeated failure in previous IVF treatments (\> than 4 cycles)
- •Sperm used for treatment was retrieved by surgical procedure
Arms & Interventions
Follicular Estrogen, Antagonist, IVF
Follicular Estrogen in Antagonist IVF protocol
Intervention: estradiol valerate
long IVF protocol
long IVF protocol
Intervention: estradiol valerate
Outcomes
Primary Outcomes
ovum pickup rate that took place between Sunday to Thursday without a compromise
Time Frame: a year
number of Pickups that took place between Sunday to Thursday (without a compromise in treatment) \\ by the entire pickup number
Secondary Outcomes
- pregnancy rate(a year)