NCT01489852
Completed
Phase 4
Interest of a Steroid Pre-treatment Prior to IVF Protocol With Ovarian Stimulation by Recombinant FSH and With LH Surge Blockage by Daily GnRH Antagonist
Gemer1 site in 1 country472 target enrollmentDecember 2006
Overview
- Phase
- Phase 4
- Intervention
- 17beta-estradiol
- Conditions
- Infertility
- Sponsor
- Gemer
- Enrollment
- 472
- Locations
- 1
- Primary Endpoint
- number of retrieved oocytes
- Status
- Completed
- Last Updated
- 14 years ago
Overview
Brief Summary
The purpose of this study is to assess whether estrogen pre-treatment can allow retrieval of 2 additional oocytes in GnRH antagonist protocol.
Investigators
Dr CEDRIN-DURNERIN Isabelle
principal investigator
Gemer
Eligibility Criteria
Inclusion Criteria
- •regular normo-ovulatory cycles (28 to 35 days)
- •age \< 38 years,
- •body mass index (BMI) between 18 and 30
- •first or second IVF/ICSI attempt
Exclusion Criteria
- •high basal levels of serum FSH or E2,
- •less than 5 follicles at the antral follicular count performed on day 3 of a spontaneous cycle,
- •history of high (\>20 oocytes) or low (\< 5 oocytes) ovarian response in a previous IVF attempt
Arms & Interventions
Estrogen pre-treatment
Intervention: 17beta-estradiol
Outcomes
Primary Outcomes
number of retrieved oocytes
Time Frame: at the ovarian puncture, 36 hours post HCG administration
Secondary Outcomes
- delivery rate(9 months later)
- number of obtained embryos(2 days after in vitro fertilization)
- pregnancy rate(at pregnancy test and at 6 Week US examination)
- duration of FSH administration(at the end of ovarian stimulation usually after a mean of 12 days of administration)
- Total FSH dose(at the end of ovarian stimulation usually after a mean of 12 days of administration)
Study Sites (1)
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