Fetuin A Association in Periodontal Disease and Diabetes Mellitus

Completed

• Conditions: Periodontitis, Adult
• Interventions: Diagnostic Test: GCF levels of fetuin A and hsCRP evaluation

• Registration Number: NCT06064786
• Lead Sponsor: Fayoum University

Brief Summary

Aim: The aim of the current study was to compare and correlate gingival crevicular fluid (GCF) fetuin-A levels and high sensitivity C-reactive protein (hs-CRP) levels in non-diabetic periodontitis patients and type 2 diabetic periodontitis patients with healthy subjects and revealing its possible role in diagnosis of periodontal disease.

Methodology: Forty-five periodontitis stage III patients categorized into 3 groups according to whether having type II diabetes mellitus or not were compared to systemically and periodontally healthy participants in this investigation. Clinical parameters for all groups were recorded. Assessment of GCF levels of fetuin A and hs-CRP were done to all enrolled participants utilizing an enzyme linked immune-sorbent assay (ELISA) kit. Receiver operating characteristic (ROC) curve was performed to reveal sensitivity, specificity, predictive value and diagnostic accuracy of the markers used.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-08-01
• Status Verified: 2023-09
• Primary Completion: 2023-09-15
• Study Completion: 2023-09-15
• Study First Submitted: 2023-09-20
• Study First Submitted QC: 2023-09-26
• Last Update Submitted: 2023-09-26
• Study First Posted: 2023-10-03
• Last Update Posted: 2023-10-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

• both gender periodontitis stage III

Exclusion Criteria

1. Smoking,
2. Systemic diseases (except DM in group B),
3. Periodontitis patients having periodontal treatment recently (past 6 months),
4. Pregnancy, lactation, contraceptive pills,
5. Anti-inflammatory/ immunosuppressive drugs.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Group I	GCF levels of fetuin A and hsCRP evaluation	15 healthy patients with generalized periodontitis stage III.
Group II	GCF levels of fetuin A and hsCRP evaluation	15 patients suffering from type 2 diabetes mellitus with generalized periodontitis stage III
Group III	GCF levels of fetuin A and hsCRP evaluation	15 systemically healthy patients without periodontitis

Primary Outcome Measures

Name	Time	Method
GCF levels of fetuin A and hsCRP evaluation in all groups	levels of fetuin A and hsCRP are measured at baseline after the completion of all GCF sample collection carried at the day of enrollment of subjects in the investigation after diagnosis confirmation	ELIZA kits

Trial Locations

Locations (1)

faculty of dentistry, Fayoum university; 🇪🇬 Fayoum, Egypt