Gastric emptying and post-meal blood sugar and gut hormones responses in healthy Indigenous Australians

Not Applicable

Recruiting

• Conditions: Diabetes; Metabolic and Endocrine - Diabetes

• Registration Number: ACTRN12620000367943
• Lead Sponsor: Royal Adelaide Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-03-17
• Last Update Posted: 23 March 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

A) For all participants:
•Male and female aged 18 – 70 years
•Body mass index (BMI) 20 - 30 kg/m2
•Normotensive (BP < 140/90)
•Haemoglobin in the normal range.
•Ability to understand the Participant Information and Consent Form and provide written consent.

B) For inclusion in the Aboriginal cohort, the following applies:
For the purposes of the study, a participant will be considered an ‘Aboriginal’ if he or she fulfills the three-part definition of an Aboriginal person proposed by the Commonwealth Department of Aboriginal Affairs i.e. An Aboriginal or Torres Strait Islander is a person of Aboriginal or Torres Strait Islander descent who identifies as an Aboriginal or Torres Strait Islander and is accepted as such by the community in which he [or she] lives”.

Exclusion Criteria

•Glycated haemoglobin greater than 6.5%
•Past history of gastrointestinal surgery (except appendicectomy)
•Medication(s) which may affect gastrointestinal motor function, body weight or appetite
•Other significant illness, including epilepsy, cardiovascular or respiratory disease
•History of gastrointestinal disease, including pancreatitis, chronic abdominal symptoms
•Evidence of drug abuse, consumption of more than 20 g alcohol or 10 cigarettes per day
•Impaired renal function (eGFR of less than 60 mL/min/1.73 m2).
•Impaired liver function (liver enzymes greater than twice the upper limit of normal).
•Donation of blood within the previous 3 months
•Radiation exposure within the past 12 months for research studies
•Pregnant or breast-feeding women

Study & Design

• Study Type: Interventional
• Study Design: Not specified