Effect of Reduction of Inflammatory Status on Glucose Metabolism in Overweight Men

Not Applicable

Completed

• Conditions: Overweight; Obesity; Inflammation

• Registration Number: NCT00221052
• Lead Sponsor: TNO

Brief Summary

Overweight increases the risk to develop chronic diseases including type-2 diabetes and cardiovascular disease. The low-grade inflammatory status often seen in overweight subjects is thought to play an important role in disease development.

The purpose of this study is to determine the role of inflammation on glucose metabolism and insulin resistance. In this study the effect of the anti-inflammatory treatment diclofenac on markers of inflammation and on parameters of glucose metabolism will be studied.

Detailed Description

Not available

Study Timeline

• Study Start: 2005-06
• Study Completion: 2005-07
• Study First Submitted: 2005-09-13
• Study First Submitted QC: 2005-09-13
• Study First Posted: 2005-09-22
• Status Verified: 2006-10
• Last Update Submitted: 2006-10-10
• Last Update Posted: 2006-10-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 20

Inclusion Criteria

• Body Mass Index (BMI): 25.1 - 32.0 kg/m2
• Normal Dutch eating habits

Exclusion Criteria

• diabetes, cardiovascular disease or hypertension
• Not suitable to receive diclofenac treatment
• Smoking
• Extreme physical activity (more than 6 hours/week)
• Reported slimming or medically prescribed diet

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Trial Locations

Locations (1)

TNO Quality of Life; 🇳🇱 Zeist, Netherlands