Hypercoagulability and Liver Function After Major Liver Resection
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Establish a relationship between ICG and MCF
研究概览
简要总结
The aim of this study is to evaluate early clotting disorders through thromboelastogram and anticoagulant proteins levels (maybe also endothelial markers) and liver function by indocyanine green clearance after major liver resection and search for a potential relationship between them.
详细描述
We are prospectively recording data from patients undergoing major liver resection. We obtain a full procoagulant and anticoagulant profile preoperatively and, at first, second and sixth day after surgery. We also measure indocyanine green (ICG) clearance preoperatively and in the first two postoperative days. We are also recording clinical data, focusing on medical and surgical complications. We aim to establish the potential value of ICG clearance and or coagulation profile to predict clinical complications
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing major liver surgery defined as resection of 3 or more hepatic segments
排除标准
- •Indocyanin green allergy
- •Thyrotoxicosis
- •Thrombophilia
- •Lupus anticoagulant
- •Coagulation factor deficiency
- •Venous thromboembolism in the last 3 years
- •Pulmonary thromboembolism in the last 3 years
研究组 & 干预措施
IGC and thromboelastometry
Patients that have hyper, normo o hypcoagulability measured by tromboelastometry and anticoagulant proteins levels early after major liver resection and clinical evolution and patients with liver funcion impairment or without it, measured by indocyanine green clearance early after surgery and clinical evolution
干预措施: Indocyanine green clearance (Drug)
IGC and thromboelastometry
Patients that have hyper, normo o hypcoagulability measured by tromboelastometry and anticoagulant proteins levels early after major liver resection and clinical evolution and patients with liver funcion impairment or without it, measured by indocyanine green clearance early after surgery and clinical evolution
干预措施: Thromboelastometry (Other)
结局指标
主要结局
Establish a relationship between ICG and MCF
时间窗: 1 week
We aim to find a potential association between ICG and MCF measured by thromboelastometry in the first week after surgery
Establish a relationship between pro and anticoagulant proteins levels and endothelial markers
时间窗: 1 week
We aim to find a potential association between procoagulant factor levels, protein C,S and ATIII with thrombomodulin, heparan sulfate and syndecan-1 in the first week after surgery
次要结局
- Study blood coagulation disorders after major liver surgery resection(2 years)
- Study liver function after major liver surgery(2 years)
研究者
Patricia Duque González
MD, PhD
Hospital General Universitario Gregorio Marañon