Coagulation Disturbances and Thrombosis in Acute Pancreatitis (Koagulopati Och Trombos Vid Akut Pankreatit-APK Studien)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- Region Skane
- 入组人数
- 141
- 试验地点
- 2
- 主要终点
- Severe acute pancreatitis
研究概览
简要总结
The study aims to investigate pathophysiological changes in coagulation in relation to inflammation in patients with acute pancreatitis. Serum and plasma is sampled repeated days from admission. Analysis will be done after recruitment. Specific biomarkers accuracy for prediction of moderate and severer acute pancreatitis will be calculated.
详细描述
Inclusion criteria:
Patients with acute pancreatitis admitted to Skåne University Hospital in Malmö
Acute pancreatitis is defined as minimum 2 out of following: amylase levels >3 times upper reference limit, clinical signs of acute pancreatitis, imaging findings of acute pancreatitis)
Exclusion criteria:
<18 years of age
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Acute Pancreatitis, accept informed consent -
排除标准
- •More than 72h from onset of symptoms until first sample, patient already included once
研究组 & 干预措施
Mild acute pancreatitis
Groups are defined by the Revised Atlanta classification. Anticipated 60% mild, 30% moderate and 10% severe patients
干预措施: Exploratory for different markers (Diagnostic Test)
moderately severe acute pancreatitis
Groups are defined by the Revised Atlanta classification. Anticipated 60% mild, 30% moderate and 10% severe patients
干预措施: Exploratory for different markers (Diagnostic Test)
severe acute pancreatitis
Groups are defined by the Revised Atlanta classification. Anticipated 60% mild, 30% moderate and 10% severe patients
干预措施: Exploratory for different markers (Diagnostic Test)
结局指标
主要结局
Severe acute pancreatitis
时间窗: 14 days
According to Revised Atlanta which is a consensus document where organ failure (defined by modified Marshall score) less than 48hours or signs of local complications on CT scan defines severity. This is not a scale but a generally used definition according to the paper: Banks PA, et al. Classification of acute pancreatitis-2012: revision of the Atlanta classification and definitions by international consensus. Gut. 2013;62(1):102-11.
次要结局
- Moderately Severe Acute Pancreatitis(14 days)