Coagulation and Fibrinolysis as Virulence Factors for Invasive Staphylococcus Aureus and Streptococcus Infections

Completed

• Conditions: Necrotizing Fasciitis; Infective Endocarditis

• Registration Number: NCT01731483
• Lead Sponsor: Universitaire Ziekenhuizen KU Leuven

Brief Summary

the aim of this study is to investigate the role of staphylokinase, streptokinase and MMP activation in invasive staphylococcal and streptococcal infections.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-07
• Study First Submitted: 2012-11-15
• Study First Submitted QC: 2012-11-20
• Study First Posted: 2012-11-21
• Primary Completion: 2020-03
• Study Completion: 2020-03-18
• Status Verified: 2023-08
• Last Update Submitted: 2023-09-01
• Last Update Posted: 2023-09-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 89

Inclusion Criteria

• all patients that undergo surgical treatment for invasive streptococcal or staphylococcal infections, including acute infective endocarditis and necrotizing fasciitis, from the UZ Leuven University Hospital

Exclusion Criteria

• none

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
proteolytic activity	1 day (on date of surgery (tissue sample))

Trial Locations

Locations (1)

UZ Leuven University Hospital; 🇧🇪 Leuven, Belgium