NL-OMON48961CompletedNot Applicable
''Dynamic exercise muscle metabolism in Spinal Muscular Atrophy type 3 assessed by 31-Phosphorus Magnetic Resonance Spectroscopy'' - MRS in SMA
niversitair Medisch Centrum Utrecht0 sites30 target enrollmentStarted: TBDLast updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 30
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Observational invasive
Eligibility Criteria
- Ages
- 12 to 99 (—)
Inclusion Criteria
- •Genetically confirmed diagnosis of SMA type 3/4 OR gender and age matched
- •healthy controlsAge 12 and olderInformed consent/ parental informed consent
- •Ability to perform active arm cycling movements in a supine positionAbility to
- •follow test instructionsSufficient understanding of the Dutch languageM.
- •Biceps MRC * 4 and M. Triceps MRC * 2
- •M. Quadriceps MRC * 3 and M. Psoas MRC * 2
Exclusion Criteria
- •Ineligible to perform an exercise testPregnancy (Other) relevant medical
- •disorders; i.e. comorbidities affecting exercise tolerance Being under
- •examination for non-diagnosed disease at the time of investigation
- •Contra-indications concerning MRS assessmentRisk factors for exercise testing
- •registered by a Dutch version of the Preparticipation Questionnaire (American
- •College of Sports Medicine and American heart Association). Possible risk
- •factors will be discussed with a medical specialist or general practitioner
- •before a subject can be included
- •andere vormen
Investigators
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