Comparison of two methods of pain relief after open gynecological cancer surgery - Bilateral rectus sheath block with multimodal analgesia versus intrathecal morphine
- Conditions
- Health Condition 1: null- Gynaecological cancer patients scheduled for open surgery
- Registration Number
- CTRI/2017/01/007730
- Lead Sponsor
- Vimi Rewari
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 90
Inclusion Criteria:
• > 18 years of age
•Planned major abdominal surgery for gynaecological cancer with open midline surgical incision
•Willing and able to consent and communicate properly
•American Society of Anaesthesiologists (ASA) I â?? III
Exclusion Criteria:
•Consent refused
•ASA >III
•Contraindications to regional technique e.g allergy to local anaesthesia, infection around site of block , coagulation disorder and sepsis
•History of analgesic dependence (long term use) and opiate tolerance
•Difficulty with communication
•Pre-existing chronic abdominal pain
•Use of any analgesic (opioid, acetaminophen, NSAIDS) within 24 hours of surgery
•Diabetes or Renal insufficiency
•Concurrent additional surgery at another anatomical site
•Extensive existing midline abdominal scarring
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Total postoperative morphine consumption as administered by intravenous patient-controlled analgesia (PCA) in the Post Anaesthesia Care Unit (PACU)Timepoint: 24 hrs postoperatively
- Secondary Outcome Measures
Name Time Method 1.Time to first request for analgesia or VAS (Visual Analogue Scale) 4 <br/ ><br>2.Pain scores as measured by the VAS score at rest and on movement (Flexion of legs at the knee joint) at 0, ½, 1, 2, 4, 6, 12 and 24 hours postoperatively <br/ ><br>3.Incidence of side effects of opioids <br/ ><br>�Respiratory depression , sedation, pruritus and postoperative nausea and vomiting <br/ ><br>4.Time to return of intestinal function ( Passage of flatus) <br/ ><br>5.Patient satisfaction with the analgesic regime <br/ ><br>Timepoint: 0, ½, 1, 2, 4, 6, 12 and 24 hours postoperatively