Efficacy of minodronic acid hydrate in patients with osteoporosis
- Conditions
- osteoporosis
- Registration Number
- JPRN-UMIN000011846
- Lead Sponsor
- Tottori University, Faculty of Medicine, School of Health Science
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- Female
- Target Recruitment
- 120
Not provided
1)Secondary osteoporotic patient 2)Patients with peptic ulcers 3)Patients with history of gastrectomy or broad gastrointestinal resection 4)Patients who diagnosed malignancy 4)Patients with obstacles which delays esophagus passage of stricture of the esophagus or achalasia 5) Patients who have raised the upper part of the body for 30 minutes or it cannot be standing 6) Patients with hypersensitivity to bisphosphonates 7)Patients with receiving therapy of SERM or bisphosphonates 8)Patients with receiving therapy of drugs affecting bone metabolism within 8 weeks before study 9)Patients with hypocalcemia 10)Patients with severe hepatic and renal dusfunction and cardiovascular disease 11)Patients with pregnancy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method (1)Newly diagnosed Osteoporotic patients -Changes in bone metabolic markers -Changes in QOL score(SF-8) (2) Other bisphosphonates-treatment resistant osteoporotic patients. -Changes in bone mineral density -Changes in hip structure analysis
- Secondary Outcome Measures
Name Time Method (1)Newly diagnosed Osteoporotic patients -Correlation between bone metabolic markers -Correlation between the number of incident fracture and the efficacy of MIN -Incidence of new vertebral fracture -Adherence to MIN - Incidence of side effects (2) Other bisphosphonates-treatment resistant osteoporotic patients. -Changes in bone metabolic markers -Correlation between bone metabolic markers and bone mineral density -Correlation between the number of incident fracture and the efficacy of MIN -Incidence of new vertebral fracture -Adherence to MIN - Incidence of side effects