NCT06939387RecruitingNot Applicable
Establishment, Evaluation and Treatment Strategy of Drug-induced Kidney Injury Model
Zhejiang Provincial People's Hospital1 site in 1 country1,500 target enrollmentStarted: March 10, 2025Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Enrollment
- 1,500
- Locations
- 1
- Primary Endpoint
- Model performance metrics assessed by AUC-ROC, accuracy and F1-score using 10-fold cross-validation
Study Overview
Brief Summary
To establish the prediction model of renal dysfunction in patients with drug-induced renal injury and study the prognosis of different drug treatments
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Other
Eligibility Criteria
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Drug-induce acute kidney injury
Exclusion Criteria
- •1.Dialysis patients; 2.No baseline creatinine; 3.Obstructive AKI; 4.Clinical data were incomplete.
Outcomes
Primary Outcomes
Model performance metrics assessed by AUC-ROC, accuracy and F1-score using 10-fold cross-validation
Time Frame: through study completion, an average of 6 months
The prognosis of renal function was evaluated by measuring creatinine and proteinuria by laboratory tests. Predict outcomes using machine learning methods. And the prediction effect of the prediction model was evaluated by AUC-ROC, F1, accuracy and other indicators.
Secondary Outcomes
- The rate at which creatinine falls(7 days, 1 month, 3 months after treatment)
Investigators
Study Sites (1)
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