The Impact of Renal Impairment on the Pharmacokinetic and Pharmacodynamic of LEO 27847

Phase 1

Completed

• Conditions: Renal Impairment
• Interventions: Drug: LEO 27847

• Registration Number: NCT01141179
• Lead Sponsor: LEO Pharma

Brief Summary

The study will investigate the impact of reduced renal function on the pharmacokinetic and pharmacodynamic profile of LEO 27847. Volunteers with different degrees of renal impairment will be administered one dose of the investigational drug and then followed until investigational drug is eliminated from the body.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-05
• Study First Submitted: 2010-06-09
• Study First Submitted QC: 2010-06-09
• Study First Posted: 2010-06-10
• Primary Completion: 2011-02
• Study Completion: 2011-02
• Status Verified: 2013-11
• Last Update Submitted: 2025-02-21
• Last Update Posted: 2025-02-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

• Male and/or non-childbearing potential female, 18 years of age and older, healthy or with stable renal impairment (deemed stable by the referring physician for at least the last 4 weeks and not expected to change significantly during the next 3 months)

• BMI ≥18.0 and ≤ 42 kg/m2

• Patients with stable concomitant medical conditions

• Healthy subjects or patients with a creatinine clearance (at the time of screening) estimated using the formula of Cockcroft and Gault within the range of:

  • ≥ 50 to ≤ 80 mL/min (Mild Group: 8 subjects),
  • ≥ 30 to < 50 mL/min (Moderate Group: 8 subjects),
  • < 30 mL/min (Severe Group: 8 subjects).

Main

Exclusion Criteria

• Patients with renal transplants or currently on haemodialysis or peritoneal dialysis

• Clinically significant illness or surgery within 4 weeks prior to dosing

• Clinically significant ECG abnormalities or vital sign abnormalities at screening

• History of stroke, cerebrovascular disorder, coronary angioplasty and coronary bypass graft

• Clinically significant history or presence of any gastrointestinal pathology

• Use of medications other than their stable medications within 14 days prior to administration of investigational product or over-the-counter products within 7 days prior to administration of investigational product, except for:

  • multivitamins or vitamin D taken on a regular basis
  • topical products without systemic absorption

• Hemoglobin ≤ 90 g/L

• Serum total calcium (adjusted for albumin) level < 2.25 mmol/L

• Clinically significant history of congestive heart failure, cardiac dysfunction or liver disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
LEO 27847	LEO 27847	-

Primary Outcome Measures

Name	Time	Method
PK parameters	1 week	(AUC, Cmax)in each group of renal impairment

Secondary Outcome Measures

Name	Time	Method
PD parameters	1 week	(Calcium, phosphate, PTH), Vitamin D in each group of renal impairment

Trial Locations

Locations (1)

Anapharm; 🇨🇦 Toronto, Ontario, Canada