The Impact of Renal Impairment on the Pharmacokinetic and Pharmacodynamic of LEO 27847

LEO Pharma1 site in 1 country25 target enrollmentMay 2010

ConditionsRenal Impairment

InterventionsLEO 27847

Overview

Phase: Phase 1
Intervention: LEO 27847
Conditions: Renal Impairment
Sponsor: LEO Pharma
Enrollment: 25
Locations: 1
Primary Endpoint: PK parameters
Status: Completed
Last Updated: last year

Overview Investigators Eligibility Criteria Arms & Interventions Outcomes Sites Similar Trials

Overview

Brief Summary

The study will investigate the impact of reduced renal function on the pharmacokinetic and pharmacodynamic profile of LEO 27847. Volunteers with different degrees of renal impairment will be administered one dose of the investigational drug and then followed until investigational drug is eliminated from the body.

Registry

clinicaltrials.gov

Start Date

May 2010

End Date

February 2011

Last Updated

last year

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

LEO Pharma

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Male and/or non-childbearing potential female, 18 years of age and older, healthy or with stable renal impairment (deemed stable by the referring physician for at least the last 4 weeks and not expected to change significantly during the next 3 months)
•BMI ≥18.0 and ≤ 42 kg/m2
•Patients with stable concomitant medical conditions
•Healthy subjects or patients with a creatinine clearance (at the time of screening) estimated using the formula of Cockcroft and Gault within the range of:
•≥ 50 to ≤ 80 mL/min (Mild Group: 8 subjects),
•≥ 30 to \< 50 mL/min (Moderate Group: 8 subjects),
•\< 30 mL/min (Severe Group: 8 subjects).

Exclusion Criteria

•Patients with renal transplants or currently on haemodialysis or peritoneal dialysis
•Clinically significant illness or surgery within 4 weeks prior to dosing
•Clinically significant ECG abnormalities or vital sign abnormalities at screening
•History of stroke, cerebrovascular disorder, coronary angioplasty and coronary bypass graft
•Clinically significant history or presence of any gastrointestinal pathology
•Use of medications other than their stable medications within 14 days prior to administration of investigational product or over-the-counter products within 7 days prior to administration of investigational product, except for:
•multivitamins or vitamin D taken on a regular basis
•topical products without systemic absorption
•Hemoglobin ≤ 90 g/L
•Serum total calcium (adjusted for albumin) level \< 2.25 mmol/L