Breatheomics of mechanically ventilated intensive care patients.
Recruiting
- Conditions
- SIRS and sepsis and critical illness related organ failure
- Registration Number
- NL-OMON26899
- Lead Sponsor
- Academic Medical Center, Amsterdam
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 1500
Inclusion Criteria
Intubation and mechanically ventilation and an expected ICU-stay > 24 hours.
Exclusion Criteria
1. Age < 18 years;
2. Expected pregnancy.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Breathprints obtained by electronic nose (Cyranose and ContiNose);<br /><br>2. Specific VOCs detected by GC-MS.
- Secondary Outcome Measures
Name Time Method 1. Sepsis and probability of infection;<br /><br>2. Organ failure;<br /><br>3. Systemic biomarkers of inflammation, coagulation, organ failure, etc;<br /><br>4. Pulmonary biomarkers of inflammation, coagulation, etc;<br /> <br>5. Pulmonary microbiome.<br><br /><br /><br>Other:<br /><br>General demographical, clinical and physiological data are collected for calculation of acute physiology, age and chronic health (APACHE) II and III scores, simplified acute physiology scores (SAPS) II, and sequential organ failure assessment (SOFA) scores. Daily laboratory include WBC & differentials, platelet counts, creatinine, ASAT, ALAT, glucose, PT, aPTT, and lactate. Infections on admission and during stay on the ICU are recorded. Outcome data include duration of mechanical ventilation, length of stay in ICU and hospital, and 30–day -, 90–day - and 1–year mortality.