Ventilator Mode and Respiratory Physiology
- Conditions
- Pulmonary DiseaseRespiratory FailureRespiratory EffortBreathing Mechanics
- Interventions
- Other: lung mechanics, respiratory drive and effort
- Registration Number
- NCT06624254
- Lead Sponsor
- University of California, San Diego
- Brief Summary
Modern intensive care units (ICUs) are increasingly adopting newer modes of mechanical ventilation such as adaptive pressure control (APC) modes but there are limited data available regarding risks and benefits of newer modes versus traditional ventilation modes. APC can inadvertently deliver high tidal volumes, which maybe harmful. High tidal volumes may be unrecognized by the provider, due to the complexities of ventilator algorithms and patient interactions. The objective of this aim is to identify risk factors for excess tidal volumes in patients on adaptive pressure control.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ENROLLING_BY_INVITATION
- Sex
- All
- Target Recruitment
- 60
- Admitted to ICU with acute respiratory failure
- On adaptive pressure control mode of ventilation
- Tidal volumes set between 5-8 cc/kg ideal body weight
- Current use of neuromuscular blockade
- Inability to obtain consent from patient or surrogate decision maker
- Treating clinician refusal
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Adaptive Pressure Control lung mechanics, respiratory drive and effort On adaptive pressure control mode with acute respiratory failure
- Primary Outcome Measures
Name Time Method Excess tidal volume From enrollment to end of monitoring at 4 hours Exhaled tidal volume greater than 2cc/kg ideal body weight above intended or set tidal volume
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University of California San Diego Health
🇺🇸La Jolla, California, United States