The impact of probiotics and prebiotics on dry eye disease

Not Applicable

• Conditions: Dry eye discomfort; Eye - Diseases / disorders of the eye

• Registration Number: ACTRN12624000444583
• Lead Sponsor: SW School of Optometry and Science Vision

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2021-12-01
• Study Start: 2024-04-10
• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Stopped early
• Sex: All
• Target Recruitment: 41

Inclusion Criteria

-be able to read and comprehend English and give informed consent as demonstrated by signing a record of informed consent
-No previous probiotic or fermented product intake in the last three months
-Currently have been diagnosed with dry eye disease
-Be at least 18 years old
-Be willing to comply with the consuming probiotic product and clinical trial visit schedule
-Be willing to discontinue all ophthalmic preparations including artificial tears during the study and 72 hours before screening

Exclusion Criteria

- Currently taking probiotics or other fermented products. Participants will be advised not to change their diet for the duration of the study.
-Any systemic or topical medications that will affect ocular physiology or tear film layer e.g. anti-acne medications such as Roaccutane and corticosteroids or immunosuppressant medications such as Hydrocortisone, Prednisolone.
-Any systemic disease that may affect ocular health e.g. diabetes, Graves’ disease, and auto-immune diseases such as ankylosing spondylitis, multiple sclerosis, Sjögren’s syndrome, Crohn’s disease, elevated CRP, IBS, Inflammatory bowel disease and systemic lupus erythematosus.
-Eye surgery within 12 weeks immediately prior to enrolment for this trial
-Previous corneal refractive surgery
-Active corneal infection or any active ocular disease such as iritis, corneal edema or corneal dystrophies, including anterior membrane dystrophy
-Any current ocular injury
-Taking oral or topical antibiotics
-Be currently enrolled in another clinical trial or have participated in a clinical trial within the previous 2 weeks.
-pregnant or lactating

Study & Design

• Study Type: Interventional
• Study Design: Not specified