Investigating the effect of probiotics on the clinical symptoms of children with eosinophilic gastroenteritis

Phase 2

Recruiting

Conditions: Eosinophilic gastroenteritis.
Eosinophilic gastritis or gastroenteritis
K52.81

Registration Number: IRCT20240419061527N1

Lead Sponsor: Tehran University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 50

Inclusion Criteria

Definitive diagnosis of eosinophilic gastritis based on the following diagnostic criteria In pathological view =30 Eo/HPF in =5 HPF or =70 Eo/HPF in =3 HPF (stomach) =52 Eo/HPF (duodenum) =56 Eo/HPF (ileum) In endoscopic view: micronodules, erogenous and mucosal hyperemia
Parents' consent to participate in the study

Exclusion Criteria

Non-compliance with the patient's medication
Incompleteness of information
Cortone/PPI/antibiotics use
Patients with immune deficiency
Other eosinophilic diseases such as IBD, celiac disease, parasitic diseases and Crohn's disease
Cases of disturbed thyroid tests that require treatment

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Improving digestive symptoms (abdominal pain, diarrhea, nausea and vomiting, and constipation). Timepoint: At the beginning of the study and 10 weeks after the start of treatment. Method of measurement: Check clinical symptoms by asking the patient and family.;The recovery rate in the endoscopic view (number of micronodules, number of erogenous and mucosal hyperemia). Timepoint: At the beginning of the study and 10 weeks after the start of treatment. Method of measurement: Based on endoscopy and gastroenterologist diagnosis.

Secondary Outcome Measures