The Effect of Cold Storage Solutions on Ischemic Injury in Lung Transplantation

Phase 3

Completed

• Conditions: Lung Transplant Recipients

• Registration Number: NCT00284726
• Lead Sponsor: Johns Hopkins University

Brief Summary

The purpose of this study is to compare 2 different cold storage solutions, used to preserve donor lungs for lung transplantation, and their effect on cytokine activation related to ischemic reperfusion injury. Primary endpoint is 30 day survival.

Detailed Description

The length of ischemic time in harvesting lung allografts is associated with graft survival. It is further thought that ischemic changes in early post-transplantation bronchoscopic biopsies has a direct correlation with later development of chronic rejection.

Study Timeline

• Study Start: 2000-12
• Study Completion: 2005-09
• Study First Submitted: 2006-01-31
• Study First Submitted QC: 2006-01-31
• Study First Posted: 2006-02-01
• Status Verified: 2017-12
• Last Update Submitted: 2023-09-26
• Last Update Posted: 2023-09-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

Any patient undergoing a lung trasnplant at Johns Hopkins Hospital -

Exclusion Criteria

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: Not specified