End-of-life Decision-making in Patients With Sepsis-related Organ Failure

Not Applicable

• Conditions: severe sepsis; A41.9; Sepsis, unspecified

• Registration Number: DRKS00000619
• Lead Sponsor: Integriertes Forschungs- und Behandlungszentrum (IFB)Sepsis und SepsisfolgenCenter for Sepsis Control and Care (CSCC)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2010-11-29
• Study Completion: 2016-08-24
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 496

Inclusion Criteria

patients with severe sepsis

Exclusion Criteria

brain dead patients receiving therapy for organ donation

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1 Symptoms of burnout by MBI score in ICU caregivers (planned enrolment: n=180 in each period) <br>2 Symptoms of post-traumatic stress disorder by IES and HADS scores in relatives after approximately 60 - 90 days (planned enrolment n=90 in each period)

Secondary Outcome Measures

Name	Time	Method
Psychological symptoms by IES, HADS or MBI subcales in caregivers or relatives, respectively; <br><br>Characteristics of patients with and without end-of-life decisions (EOL-D) including time periods (time until EOL-D, time between EOL-D until death or discharge) and 28-day and 90-day mortality rates; <br><br>Prevalence and characteristics of EOL-D; <br><br>Prevalence and characteristics of patients' advance directives; <br><br>Characteristics of EOL-D communication with relatives; <br><br>Prevalence of request for Ethik Konsil (counseling by an external ethical review board); <br><br>Direct costs of treatment of survivors and non-survivors;