Generalised hyperalgesia and mechanical pain thresholds in chronic lumbar pain syndromes with and without psychosocial chronicising factors

• Conditions: M54; Dorsalgia

• Registration Number: DRKS00028286
• Lead Sponsor: niversitätsmedizin Halle/Saale, Department für Orthopädie, Unfall- und Wiederherstellungschirurgie

Brief Summary

At baseline, patients with psychosocial risk factors showed significantly lower local and peripheral pressure pain thresholds, suggesting central sensitization, compared to the control group. Sleep quality, measured by the Pittsburgh Sleep Quality Index (PSQI), was also correlated with altered PPTs. After multimodal therapy, all participants reported increased local pain thresholds compared to at admission, independent of psychosocial chronification factors.

Detailed Description

Not available

Study Timeline

• Study Completion: 2016-02-29
• Study Start: 2022-04-04
• Results First Posted: 2023-02-19
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

lumbar back pain > 12 weeks
- indication for inpatient multimodal pain/complex therapy

Exclusion Criteria

- condition after spinal surgery
- trauma, infection or tumours of the spine
- pregnancy or breastfeeding

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
lokal and peripheral ain pressure thresholds at admission and discharge (T1: 14 days later), measured with a algometer for pressure pain thresholds

Secondary Outcome Measures

Name	Time	Method
HADS, pain intensity, sleep quality (Pittsburgh Sleep Quality Index)