GeneMatch: A Program of the Alzheimer's Prevention Registry to Match Individuals to Studies Based on Apolipoprotein E (APOE) Genotype

• Conditions: Alzheimer Disease

• Registration Number: NCT02564692
• Lead Sponsor: Banner Health

Brief Summary

The purpose of the Alzheimer's Prevention Registry GeneMatch program is to identify a large group of people interested in participating in research studies or clinical trials based in part on their genetic background. This genetic information will be used to match interested individuals to studies, providing a recruitment resource to the Alzheimer's scientific community. Interested individuals should visit www.endALZnow.org/GeneMatch to join the GeneMatch program.

Detailed Description

The primary objectives of the Alzheimer's Prevention Registry GeneMatch program are to (1) identify and characterize a large cohort of people who are interested in, and may be eligible to participate in, current and future preclinical Alzheimer's disease research studies and clinical trials based on their genetic background, and (2) provide information to these individuals about research studies for which they may be eligible, based in part on their genetic background. Cognitively unimpaired individuals age 50 to 90, inclusive, are eligible to enroll in GeneMatch. GeneMatch will provide participants with a genetic sample kit (a cheek swab) to test for a specific gene called apolipoproteins E (APOE). GeneMatch does not disclose the results of the APOE test to participants. GeneMatch may use the APOE test results to match participants to research studies. Participants are under no obligation to pursue these study opportunities.

Study Timeline

• Study First Submitted: 2015-09-29
• Study First Submitted QC: 2015-09-29
• Study First Posted: 2015-10-01
• Study Start: 2015-11
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-19
• Last Update Posted: 2025-03-21
• Primary Completion: 2030-12
• Study Completion: 2030-12

Recruitment & Eligibility

• Status: ENROLLING_BY_INVITATION
• Sex: All
• Target Recruitment: 500000

Inclusion Criteria

• Age 50-90, inclusive
• Provide basic demographic, medical history, and contact information
• Consent to APOE genotyping without receiving results
• Live in the United States

Exclusion Criteria

• Unable to comply with this project's protocol requirements
• Self-reported diagnosis of dementia or any other objective cognitive impairment syndrome

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Number of individuals who enroll in GeneMatch	15 years

Secondary Outcome Measures

Name	Time	Method
Number of individuals referred to research studies	15 years
Number of individuals who enroll in research studies	15 years

Trial Locations

Locations (1)

Banner Alzheimer's Institute; 🇺🇸 Phoenix, Arizona, United States