Delirium Incidence and Cognitive Trajectories in Isolated Older Patients in the Inpatient Setting
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 404
- 试验地点
- 1
- 主要终点
- Delirium
研究概览
简要总结
The goal of this observational study is to examine if older patients who need to be under isolation precautions due to multidrug resistant bacteria or other reasons have an increased risk of suffering from delirium or cognitive decline compared to older patients without isolation precautions.
To compare this, every person under isolation precautions is compared to other persons of the same age, gender, comorbidities, frailty status and hospital department. Delirium is assessed twice daily with a screening tool named 3D-CAM and cognitive performance is tested by the MOCA-Test six weeks after discharge from hospital and compared to baseline values which are assessed directly after study enrollment.
The study duration for each patient participating is from the time of enrollment during hospitalization until 6 weeks after hospital discharge.
详细描述
Delirium is a common complication in older patients during hospitalization. Its prevention is crucial, as it increases morbidity, mortality, and cognitive impairment. Isolation precautions in hospital may further increase delirium risk due to sensory deprivation and reduced mobility.
This study examines the impact of isolation precautions on delirium and neurocognitive disorders in patients ≥70 years. Delirium screening will occur twice daily, with a six-week post-discharge follow-up.
A prospective cohort study will compare delirium incidence in isolated patients with a matched non-isolated control group (matched for age, gender, Charlson Comorbidity Index, Frailty and hospital department). The 3D Confusion Assessment Method (3D-CAM) will be used for Delirium screening. Follow-up assessments will evaluate cognitive function and quality of life. Data will be collected during hospitalization (Days 1-5) and six weeks post-discharge.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 70 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •hospitalized patients
- •under isolation precautions for at least 24h
- •70 years and above
排除标准
- •no informed consent
- •intensive care treatment
- •life expectancy 14 days or less
研究组 & 干预措施
Exposition
Patients under isolation precautions in hospital
Control
Matched control, no isolation precautions
结局指标
主要结局
Delirium
时间窗: day 1-5 under isolation precautions
Delirium screened by 3D-Confusion Assessment Method 2 times daily
次要结局
- Quality-of-Life (QoL)(at enrollment and 6 weeks after discharge from hospital)
- Cognitive performance(at enrollment and six weeks after discharge from hospital)
- Functional state(at enrollment and six weeks after discharge from hospital)