To compare intravenous fluid bolus and fluid plus low dose noradrenaline for preventing cardiac collapse before intubation and ventilator support
Phase 2
- Conditions
- Health Condition 1: I504- Combined systolic (congestive) anddiastolic (congestive) heart failure
- Registration Number
- CTRI/2023/07/054773
- Lead Sponsor
- Era Lucknow Medical College and Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
adult patients more than 18 years
critically ill patients needing tracheal intubation in icu
Exclusion Criteria
tracheal intubation performed outside icu/hospital setting
tracheal intubation during cardiac arrest
patients on vasoactive medications at the time of screening
hypotension SBP <90 mmhg at screening
hypertension SBP >140 mmhg at screening
urgency of tracheal intubation precludes performance of study procedures
pregnant females
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method DECREASE IN MAP 65 MMHG (2 MIN POST INDUCTION)Timepoint: DECREASE IN MAP 65 MMHG (2 MIN POST INDUCTION)
- Secondary Outcome Measures
Name Time Method . Decrease in SBP (90mmHg (2 min post induction) <br/ ><br>. New/increased vasopressor (2min post induction) <br/ ><br>.Cardiac arrest within 1 hr. <br/ ><br>. Death within 1 hr. <br/ ><br>. Ventilator-free days <br/ ><br>. noradrenaline free days <br/ ><br>. Need for RRT post intubation in ICU <br/ ><br>. Length of ICU stay <br/ ><br>. Length of hospital stay <br/ ><br>. ICU Mortality <br/ ><br>. Hospital MortalityTimepoint: Before induction and after 2 minutes of intubation