Coding of Speech Signals in the Human Auditory Nerve
- Conditions
- Hearing Loss
- Interventions
- Procedure: near field recording of human auditory nerve activity during retro sigmoid approach with contact electrode
- Registration Number
- NCT06490237
- Lead Sponsor
- CHU de Reims
- Brief Summary
The fine evaluation of the function of auditory neurons in silence and in noise in humans is difficult, if not impossible, to date with the conventional methods available. That is why in certain situations, the hearing aids of patient with hearing loss fail, especially in the presence of noise.
In this study the investigators aim at investigating the global spontaneous and sound evoked human auditory nerve activity from electrophysiological acquisitions performed directly on the cochlear nerve in patients requiring posterior fossa surgery.
- Detailed Description
The fine evaluation of the function of auditory neurons in silence and in noise in humans is difficult, if not impossible, to date with the conventional methods available. That is why in certain situations, the hearing aids of patient with hearing loss fail, especially in the presence of noise.
In this study the investigators aim at investigating the global spontaneous and sound evoked human auditory nerve activity from electrophysiological acquisitions performed directly on the cochlear nerve in patients requiring posterior fossa surgery.
Stimulations will be performed in silence and in noise from stimuli identical to those used during the preoperative auditory assessment: clic and speech syllable stimulation. These acquisitions will allow us to compare clinical and electrophysiological data in order to better understand the coding of hearing in normal and hearing loss humans under silent and noisy conditions. A prospective longitudinal study will be performed.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 60
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Subjects with no hearing loss near field recording of human auditory nerve activity during retro sigmoid approach with contact electrode - subjects with hearing loss near field recording of human auditory nerve activity during retro sigmoid approach with contact electrode -
- Primary Outcome Measures
Name Time Method Compare the amplitude of global evoked auditory nerve activity 66 months Compare the amplitude and spectrum of global evoked auditory nerve activity in silence and in noise with basic and speech stimuli between patients defined as normo and hearing loss based on preoperative audiometric tests.
Compare the spectrum of global evoked auditory nerve activity 66 months Compare the spectrum of global evoked auditory nerve activity in silence and in noise with basic and speech stimuli between patients defined as normo and hearing loss based on preoperative audiometric tests
- Secondary Outcome Measures
Name Time Method Compare the difference of coding of the fine structure 66 months Compare the difference of coding of the fine structure of the collected signal in the normo and hearing impaired groups.
Compare the difference of coding of the temporal envelope 66 months Compare the difference of coding of the temporal envelope of the collected signal in the normo and hearing impaired groups.
Compare the two groups of investigation 66 months To investigate within the group of normo hearing patients whether the spectrum of global evoked auditory nerve activity is different between those with the best and worst results in the pre-operative vocal speech in noise test.
Trial Locations
- Locations (1)
Damien JOLLY
🇫🇷Reims, France