DAT SPECT and Procedural Motor Skills in Parkinson's Disease

Not Applicable

Completed

• Conditions: Parkinson Disease
• Interventions: Behavioral: Procedural Motor Skills with mirror-drawing of figures

• Registration Number: NCT03076307
• Lead Sponsor: University Hospital, Geneva

Brief Summary

Patients with Parkinson's disease (PD) are known to be affected by subtle cognitive impairment early in the disease course, mostly in the executive field. Procedural motor skills, mainly controlled by the basal ganglia associative loop (in particular dorsal caudate nucleus) (Rodriguez-Oroz et al., 2009), have also been studied in patients with PD (Schnider et al., 1995; Muslimovic et al., 2007; Terpening et al., 2013). However, the correlation of dopaminergic 123I-FP-CIT SPECT imaging and cognitive impairment has not been assessed. One reason is the absence of reference values for striatal uptake until recently. Last year, the investigators established local uptake reference values for DAT imaging based on a large cohort of subjects with non-degenerative conditions (Nicastro et al., 2016) and can therefore use these values to precisely assess uptake loss in patients with PD.

With the present study, the investigators expect to enroll patients with early PD for whom a 123I-FP-CIT SPECT has been previously performed in the center. Subjects will perform a specific motor task based on mirror-drawing of star-shaped figures. This will be done by inverting the direction of horizontal/vertical computer mouse movements on the screen. Speed and error rates will be assessed for patients as well as healthy control subjects. Correlation with striatal SPECT uptake, especially caudate nucleus uptake, will be analyzed for PD patients. In addition, resting-state EEG will be performed for all subjects. General medication and dopaminergic drugs in particular, whenever used, will not be discontinued. For all subjects enrolled in the study, cognitive and neurological examination will be performed.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-10-18
• Study First Submitted: 2017-03-06
• Study First Submitted QC: 2017-03-06
• Study First Posted: 2017-03-10
• Primary Completion: 2017-05-20
• Status Verified: 2017-07
• Study Completion: 2017-07-19
• Last Update Submitted: 2017-07-19
• Last Update Posted: 2017-07-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 9

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Parkinson's disease	Procedural Motor Skills with mirror-drawing of figures	-
Control group	Procedural Motor Skills with mirror-drawing of figures	-

Primary Outcome Measures

Name	Time	Method
Procedural motor performance (error and time) in PD group	2 days	Evaluation of error rate and speed for completion of mirror-drawing of star-shaped figures

Secondary Outcome Measures

Name	Time	Method
Resting state EEG connectivity in PD and control groups	2 days	Evaluation of resting state EEG connectivity in both groups
Difference >20% in error rate and speed improvement in control and PD groups	2 days	Evaluation of a \>20%-difference between PD and control groups in terms of speed and error rate for the successive procedural motor task trials

Trial Locations

Locations (1)

Division of Neurorehabilitation, Geneva University Hospitals; 🇨🇭 Geneva, Switzerland