Use of Corticosteroids in Children Hospitalized With Community-acquired Pneumonia
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- Length of stay
研究概览
简要总结
The purpose of this study is to determine the efficacy of addition of corticosteroid therapy to antibiotics in children hospitalized with community-acquired pneumonia.
The hypothesis is that the use of corticosteroids decreases the length of stay in children hospitalized with community-acquired pneumonia.
详细描述
Community-acquired pneumonia (CAP) is a common problem in pediatric practice. The lower respiratory tract infections, particularly pneumonia, are a frequent cause of morbidity in children and is the leading cause of mortality in developing countries.
In the last 20 years, despite several research, only a small decrease in morbidity and mortality has been achieved.
Corticosteroids have an immune-modulation effect, not completely elucidated. Most likely, this effect is due to down regulation of pro-inflammatory cytokines.
We postulate that adding corticosteroids to antibiotic treatment of CAP might change the immune response and thereby reduce morbidity, leading to a decrease in patients hospital length of stay.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 2 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Children hospitalized for community-acquired pneumonia
- •2-18 years old
排除标准
- •Pulmonary chronic disease (including asthma)
- •Immunodeficiency
- •Diseases wich requires corticosteroids therapy (i.e. rheumatic diseases)
- •Wheezing in current disease
- •Previous hospitalization (14 days prior to admission)
- •Pleural effusion on admission
- •Malnutrition
研究组 & 干预措施
Corticosteroid
Dexamethasone 0.6 mg/kg/day or Methylprednisone 1 mg/kg/day
干预措施: corticosteroid (Drug)
结局指标
主要结局
Length of stay
时间窗: participants will be followed for the duration of hospital stay, usually 5 days
次要结局
- Length of fever(participants will be followed for the duration of hospital stay, usually 5 days)
- Length of oxygen use(participants will be followed for the duration of hospital stay, usually 5 days)