ICU patient response to tracheal suctioning with placebo, lignocaine or dexmedetomidine
- Conditions
- ICU patients
- Registration Number
- CTRI/2012/08/002898
- Lead Sponsor
- Kasturba Hospital KMC Manipal
- Brief Summary
Inour study, we evaluated the effects of two different pharmacologicalinterventions (dexmedetomidine or lidocaine) on tracheal suctioning response.
Randomisationwas done as per a computer generated randomisation table. The blinding wasensured in the following way:
**Syringe A**contained either dexmedetomidine or saline (10 mL) which was administered over5 minutes as an infusion starting from time 0 till 5th minute.
**Syringe B**contained either lidocaine or saline (5 mL) which was administered as a bolusinjection at 4th minute.
At the end of 4thminute, patients received 100% oxygen for further 60 seconds. At the end ofthis, tracheal suctioning was carried out over 15 seconds with all asepticprecautions. The tracheal suction catheter size was determined by the followingformula [Suction catheter size in French = (internal diameter of endotrachealtube in mm × 3) ÷ 2] and this was kept constant throughout the study for agiven patient.
RichmondAgitation Sedation Scale (RASS) was noted at the beginning of the study.Response to tracheal suctioning was assessed both objectively and subjectively.Observer 3 rated the pain / discomfort on a scale of 0-10 (numerical ratingscale) both prior to and after suctioning. Variables such as heart rate (HR),systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterialpressure (MAP) or any change in the rhythm pattern including ectopics *etc* were noted. These variables werenoted at every minute starting just prior to suctioning and till 5 minutesafter suctioning and then they were noted at 10th and 15thminute.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- All
- Target Recruitment
- 40
All patients that have a tracheal tube in situ in ICU.
1.Patients with known or suspected allergy to any of the study drugs (dexmedetomidine, lidocaine) 2.Patients with seizure disorder 3.Patients receiving neuromuscular blockade / with known neuromuscular disease 4.Patients who were hypotensive requiring more than one inotrope / vasopressor 5.Patients that were delirious or had disease condition that would confuse the behaviour assessment, such as decerebrate posturing.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Numerical rating scale score Baseline, at one minute interval for five minutes starting from the point of tracheal suctioning and at 10th and 15th minute following tracheal suctioning. | Behavioural response and numerical rating was assessed just prior to tracheal suctioning and in the following minute after tracheal suctioning Behavioural response score Baseline, at one minute interval for five minutes starting from the point of tracheal suctioning and at 10th and 15th minute following tracheal suctioning. | Behavioural response and numerical rating was assessed just prior to tracheal suctioning and in the following minute after tracheal suctioning Haemodynamic fluctuations of 20% from baseline Baseline, at one minute interval for five minutes starting from the point of tracheal suctioning and at 10th and 15th minute following tracheal suctioning. | Behavioural response and numerical rating was assessed just prior to tracheal suctioning and in the following minute after tracheal suctioning
- Secondary Outcome Measures
Name Time Method Complications Arrhythmias, desaturation
Trial Locations
- Locations (1)
KMC, Manipal
🇮🇳Udupi, KARNATAKA, India
KMC, Manipal🇮🇳Udupi, KARNATAKA, IndiaUmesh GPrincipal investigator9480575663drumeshg@yahoo.co.in