The Effect of Alpha-Linolenic Acid on Glycemic Control in Participants With Type 2 Diabetes
试验速览
- 阶段
- 不适用
- 入组人数
- 200
- 主要终点
- HbA1c
研究概览
简要总结
With the emerging worldwide epidemic of type 2 diabetes, dietary recommendations to improve diabetes management have been emphasized in the scientific community. Particular attention has been drawn to various benefits of replacing saturated fatty acids with unsaturated fatty acids. Alpha-linolenic acid, the only omega-3 fatty acid that is from plant sources, has been suggested by animal and cell studies to play a beneficial role in regulating blood glucose levels. However, human studies have been more inconsistent with their findings. The focus of this project is to investigate the evidence in the context of ALA and blood glucose parameters in participants with type 2 diabetes by conducting a systematic review and meta-analysis of randomized controlled trials.
研究设计
- 研究类型
- Observational
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Controlled, randomized, clinical trials
- •Trials greater than one month
- •Focusing on ALA and T2DM participants
- •Viable endpoint data
排除标准
- •Non-human studies
- •Non-random treatment allocation
- •Less than 1 month
- •Lack of suitable control
- •Lack of endpoint data
结局指标
主要结局
HbA1c
时间窗: 1 month
次要结局
- Glycated Albumin(1 month)
- HOMA- IR(1 month)
- Fructosamine(1 month)
- Fasting Blood Glucose(1 month)
- Fasting Blood Insulin(1 month)
研究者
Vladimir Vuksan
Research Scientist & Professor
Unity Health Toronto