NCT03007043已完成不适用
Genetic Variation in Gonadotropin and Gonadotropin Receptor Genes as a Causative Factor of Suboptimal Response Following Ovarian Stimulation for IVF/ICSI. A Prospective Cohort Study
Institut Universitari Dexeus2 个研究点 分布在 2 个国家目标入组 364 人开始时间: 2016年11月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 364
- 试验地点
- 2
- 主要终点
- prevalence of the main FSH receptor polymorphism
研究概览
简要总结
To evaluate the difference in the prevalence of the main FSHR polymorphism (ASN680Ser), as well as other, less studied, gonadotropin polymorphisms between ovarian response groups, following ovarian stimulation
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 38 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Age between 18-38 years old
- •Antral follicle count (AFC) > 9 or Anti-mullerian hormone (AMH) >1.1 ng/ml
- •1st or 2nd ovarian stimulation cycle for IVF/ICSI
- •Planned to undergo ovarian stimulation with 150IU of rFSH in a fixed GnRH antagonist protocol
排除标准
- •Antral follicle count (AFC) <9 and AMH<1.1 ng/ml
- •PCOS patients according to the Rotterdam criteria
- •Patients undergoing in vitro maturation (IVM)
- •Untreated endocrine abnormalities
结局指标
主要结局
prevalence of the main FSH receptor polymorphism
时间窗: 12 months
次要结局
未报告次要终点
研究者
Nikolaos Polyzos
Professor
Institut Universitari Dexeus
研究点 (2)
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