Genetic Variation in Gonadotropin and Gonadotropin Receptor Genes and Suboptimal Response

Completed

• Conditions: Fertility Disorders

• Registration Number: NCT03007043
• Lead Sponsor: Institut Universitari Dexeus

Brief Summary

To evaluate the difference in the prevalence of the main FSHR polymorphism (ASN680Ser), as well as other, less studied, gonadotropin polymorphisms between ovarian response groups, following ovarian stimulation

Detailed Description

Not available

Study Timeline

• Study Start: 2016-11
• Study First Submitted: 2016-12-28
• Study First Submitted QC: 2016-12-28
• Study First Posted: 2016-12-30
• Primary Completion: 2019-04
• Study Completion: 2019-12
• Status Verified: 2020-01
• Last Update Submitted: 2020-01-22
• Last Update Posted: 2020-01-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 364

Inclusion Criteria

1. Age between 18-38 years old
2. BMI 18-28
3. Antral follicle count (AFC) > 9 or Anti-mullerian hormone (AMH) >1.1 ng/ml
4. 1st or 2nd ovarian stimulation cycle for IVF/ICSI
5. Planned to undergo ovarian stimulation with 150IU of rFSH in a fixed GnRH antagonist protocol

Exclusion Criteria

1. Antral follicle count (AFC) <9 and AMH<1.1 ng/ml
2. PCOS patients according to the Rotterdam criteria
3. Patients undergoing in vitro maturation (IVM)
4. Untreated endocrine abnormalities

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
prevalence of the main FSH receptor polymorphism	12 months

Trial Locations

Locations (2)

Dexeus Salud de la Mujer; 🇪🇸 Barcelona, Spain

Department of Obstetrics and Gynecology, University of Medicine and Pharmacy HCMC, Ho Chi Minh City, Vietnam and Research Center for Genetics and Reproductive Health (CGRH), School of Medicine, Vietnam National University HCMC; 🇻🇳 Ho Chi Minh City, Vietnam