Impact of Gonadotrophin REceptor Polimorphisms on the Relationship Between Serum AMH and Ovarian Response
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 296
- 试验地点
- 1
- 主要终点
- Gonadotrophin receptor polymorphisms and ovarian response and AMH value
研究概览
简要总结
Aim of study: To compare the relationship between serum AMH and ovarian response for IVF with the GnRH antagonist protocol in patients who are carriers of FSH and/or LH receptor polymorphisms with those that are not.
详细描述
Serum AMH has shown to have a high predictive capability of the ovarian response to stimulation for IVF. On the other hand, patients who are carriers of polymorphisms in the FSH and LH receptors, have shown to need higher doses of gonadotrophins for ovarian stimulation. The proportion of carriers has been described to be around 20% of the population. Nevertheless, the determination of these polymorphisms is not performed in routine practice. It is unknown if their presence affects to the relationship between serum AMH levels and ovarian response.
This is a prospective, single center, non-interventional, cohorts study.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •18-45 years of age presenting to IVF clinic
- •BMI of 18-35 kg/m2
- •Having been tested for serum AMH with the Elecsys assay
- •Being planned to undergo ovarian stimulation cycle for IVF with the GnRH antagonist protocol
- •Signed written informed consent or waiver
排除标准
- •Current or past disease affecting ovaries, gonadotropin or sex steroid
- •Current hormone therapy
结局指标
主要结局
Gonadotrophin receptor polymorphisms and ovarian response and AMH value
时间窗: 1 year
To compare the relationship between serum AMH and ovarian response for IVF with the GnRH antagonist protocol in patients who are carriers of FSH and/or LH receptor polymorphisms with those that are not.
次要结局
- polymorphisms in the LH receptor (LHR) variant N312S(1 year)
- Doses of gonadotrophin needed and polymorphisms(1 year)
- polymorphisms in the FSH receptor (FSHR) variant N680S(1 year)