REOXCARE Dressing to Improve Healing in Diabetic Foot Ulcers (DFU)
- Conditions
- Neuroischemic Foot UlcerFoot UlcerDiabetes Mellitus
- Interventions
- Device: Reoxcare antioxidant dressing
- Registration Number
- NCT05413746
- Lead Sponsor
- Histocell, S.L.
- Brief Summary
It has been shown that diabetic patients present a significant increase in markers related to oxidative stress, which increases even more in those with diabetic foot ulcers and gradually depending on the severity of the injury and inversely to the mechanisms of physiological antioxidants of these patients. Therefore, these patients present a situation of oxidative stress (high lipid peroxidation), with an insufficient level of antioxidant enzymes to reverse this state, which leads to maintenance of the inflammatory situation and therefore the chronification of the ulcer. Investigators' aim in this study is to measure the benefits that the application of the product with antioxidant capacity REOXCARE can bring, together with the usual good clinical wound care guidelines and other essential therapeutic activities, such as pressure relief in the area of the ulcers.
- Detailed Description
The frequency in the appearance of diabetic foot lesions is extremely high; it is estimated that around 15% of people with diabetes will present some compromise at the level of the foot during the evolution of the disease. The high rate of recurrence of these lesions and their high mortality rate make this pathology an important health problem with high health, economic and social repercussions. Diabetic foot injury is defined as any infection, ulceration, and/or destruction of the deep tissues of the foot associated with neurological, vascular, and metabolic disorders (sustained hyperglycemia) in the lower limbs of people with diabetes. Between 40% and 70% of lower-limb amputations occur in the diabetic population, and in up to 85% of cases, the triggering factor is ulcer, associated with infection and gangrene. The incidence of a new episode after an amputation is around 50% 5 years later.
It has been shown that diabetic patients present a significant increase in markers related to oxidative stress, which increases even more in those with diabetic foot ulcers and gradually depending on the severity of the injury and inversely to the mechanisms of physiological antioxidants of these patients. Therefore, these patients present a situation of oxidative stress (high lipid peroxidation), with an insufficient level of antioxidant enzymes to reverse this state, which leads to maintenance of the inflammatory situation and therefore the chronification of the ulcer. Investigators' aim in this study is to measure the benefits that the application of the product with antioxidant capacity REOXCARE can bring, together with the usual good clinical wound care guidelines and other essential therapeutic activities, such as pressure relief in the area of the ulcers.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 20
- Post-surgical diabetic foot ulcers after an amputation process, with the purpose of closure by "secondary intention". There may be prior limb bypass surgery.
- Diabetic foot ulcers with a neuroischemic component
- Ulcers located on the foot, below the malleoli.
- Ulcers without clinical signs of infection at the time of recruitment
- Patients with sufficient physical and health characteristics to be able to respond to treatment and over 18 years of age.
- The patient and/or his/her relative/representative have given their informed consent in writing.
- In the case of several lesions in the same patient that meet the inclusion criteria, select, at the investigator's discretion, the ulcer that can best benefit from the treatment. The rest of the injuries will be treated according to clinical criteria, with the dressings available in the usual clinical practice of the Center or REOXCARE.
- Patients with wounds with clinical signs of local infection
- Intolerance to the components of the product under study.
- Uncontrolled diabetes
- Other ulcers not included in the inclusion criteria.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Antioxidant dressing (active product) Reoxcare antioxidant dressing Wound bed debridement, Antioxidant dressing (active product) application in the wound bed, covered with secondary dressing. Device: Reoxcare®
- Primary Outcome Measures
Name Time Method Changes in wound size At baseline, after 1 week, after 2 week, after 3 week, after 4 weeks, after 5 weeks, after 6 weeks, after 7 weeks and after 8 week The difference in wound area between first and last dressing Reoxcare treatment
Changes in Granulation tissue in the wound bed At baseline, after 1 week, after 2 week, after 3 week, after 4 weeks, after 5 weeks, after 6 weeks, after 7 weeks and after 8 week The percentage of granulation tissue in the wound bed is estimated by the clinicians in each week of Reoxcare treatment, At baseline and every week
- Secondary Outcome Measures
Name Time Method Time to removal of non-viable tissue from wound bed At baseline, after 1 week, after 2 week, after 3 week, after 4 weeks, after 5 weeks, after 6 weeks, after 7 weeks and after 8 week Percentage of wounds with non-viable tissue in the wound bed at each frame time
Number of completely healed wounds At baseline, after 1 week, after 2 week, after 3 week, after 4 weeks, after 5 weeks, after 6 weeks, after 7 weeks and after 8 week Number of wounds closed with respect to total number of wounds at each frame time
Trial Locations
- Locations (2)
Hospital Universitario de Cruces
🇪🇸Barakaldo, Bizkaia, Spain
Histocell
🇪🇸Derio, Vizcaya, Spain