A clinical trial to compare the outcomes between two different liver grafts in recipients and donors after live donor liver transplantatio
Not Applicable
- Conditions
- Health Condition 1: null- To study the early post operative outcomes in patients who undergoe live donor liver transplantation as per standard accepted criteria.Outcome in donors who undergoe the donor surgery is also studied
- Registration Number
- CTRI/2016/08/007186
- Lead Sponsor
- Christi Titus Varghese
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Closed to Recruitment of Participants
- Sex
- Not specified
- Target Recruitment
- 61
Inclusion Criteria
.Patients with liver disease who meet the criteria for live donor liver transplantation
.Live donor suitable for extended right hepatectomy[with middle hepatic vein]
a.Has a future liver remnant of more than 30%
b.Live donor with adequate segment 4a drainage to left hepatic vein[usually a umblical vein]
c.Steatosis less than 20% as assessed by L-S ratio on plain CT.
Exclusion Criteria
.Thrombosed recipient portal Vein.
.Graft to recipient wight ratio less than 0.7.
.Venous drainage of segment 4 mainly to middle hepatic vein in donor
.ABO incompatible liver transplants
.Donor at or above 55 years of age
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Recipient: <br/ ><br>Early Allograft Dysfuction[EAD] <br/ ><br>Small for size Syndrome[SFSS] <br/ ><br>Primary graft non function[PGNF} <br/ ><br>Patency of Middle hepatic vein <br/ ><br>Number of days in ICU <br/ ><br>Mortality at the end of 90 days <br/ ><br>Donor: <br/ ><br>Post Hepatectomy liver failure[PHLF} <br/ ><br>Post operative Clavien-Dindo score <br/ ><br>Number of days in hospital after surgery <br/ ><br>CT based volume regeneration at the end of 60 daysTimepoint: All parameters uptil discharge/one month[which ever comes later] or as specified with the outcome. <br/ ><br>
- Secondary Outcome Measures
Name Time Method Change in post surgery liver parameters in donor and recipientTimepoint: Untill discharge/ 1Month [whichever comes later]