Effects of a Liquid Meal and Gut Hormones (GIP and GLP-2) on Bone Remodeling in Participants With Hypoparathyroidism.
Not Applicable
Completed
- Conditions
- Hypoparathyroidism
- Registration Number
- NCT03728959
- Lead Sponsor
- University of Copenhagen
- Brief Summary
Hypoparathyroidism (hypoPT) is characterized by low levels of PTH.
In this study we will test the effects of a liquid meal on the bone remodeling in participants with hypoparathyroidism. Furthermore, we will test the effects of the gut hormones GIP and GLP-2.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 7
Inclusion Criteria
- Age between 18 and 76
- Hypoparathyroidism
Exclusion Criteria
- Diabetes
- Disease in the gastrointestinal tract
- Antiosteoporotic drug
- Long term steroid treatment (within the last 12 months)
- Pregnancy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Serum concentration of C-terminal telopeptide (CTX) -10 to 240 minutes Marker of bone resorption, measured in serum
N-terminal propeptide of type 1 procollagen (P1NP) -10 to 240 minutes Marker of bone formation, concentration measured in serum
- Secondary Outcome Measures
Name Time Method Glucose-dependent insulinotropic polypeptide (GIP) -10 to 240 minutes Gut hormone, concentration measured in plasma
Glucagon-like peptide-2 (GLP-2) -10 to 240 minutes Gut hormone, concentration measured in plasma
Glucagon-like peptide-1 (GLP-1) -10 to 240 minutes Gut hormone, concentration measured in plasma
Glucose -10 to 240 minutes Glucose concentration measured in serum
Insulin -10 to 240 minutes Insulin concentration measured in serum
C-peptide -10 to 240 minutes C-peptide concentration measured in serum
PTH -10 to 240 minutes PTH concentration measured in serum
Trial Locations
- Locations (1)
Hvidovre University Hospital
🇩🇰Hvidovre, Denmark
Hvidovre University Hospital🇩🇰Hvidovre, Denmark