Macronutrients and Gut Hormone Secretion

Not Applicable

Completed

• Conditions: Type 2 Diabetes

• Registration Number: NCT01366794
• Lead Sponsor: Lund University

Brief Summary

Study hypothesis is to examine the relative contribution of macronutrients for gut hormone secretion after a mixed meal in healthy volunteers and in subjects with type 2 diabetes. Individual macronutrients or a mixed meal will therefore be served and gut hormones are measured during the following 300 min.

Detailed Description

In healthy volunteers and subjects with dietary regulated diabetes mellitus, glucose, protein mixture or fat emulsion will be served individually and on a separate occasions a mixed meal will be served. Samples will be taken during the following 300 min. Concentrations of the gut hormones glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1, insulin and glucagon will be determined.

Study Timeline

• Study First Submitted: 2011-05-31
• Study First Submitted QC: 2011-06-02
• Study First Posted: 2011-06-06
• Study Start: 2011-09
• Primary Completion: 2012-12
• Study Completion: 2013-09
• Status Verified: 2014-03
• Last Update Submitted: 2014-03-14
• Last Update Posted: 2014-03-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

• Healthy status or type 2 diabetes with dietary regulation

Exclusion Criteria

• Liver disease
• kidney disease
• thyroid disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Primary Outcome Measures

Name	Time	Method
Release of gut hormones	300 min

Secondary Outcome Measures

Name	Time	Method
Insulin secretion	300 min

Trial Locations

Locations (2)

Department of Clinical Sciences Lund, Lund University; 🇸🇪 Lund, Sweden

Lund University; 🇸🇪 Lund, Sweden