Gut Hormones and Roux en Y Gastric Bypass

Not Applicable

Recruiting

• Conditions: Type 2 Diabetes; Obesity

• Registration Number: NCT01945840
• Lead Sponsor: Imperial College London

Brief Summary

The purpose of this study is to assess whether the changes in gut hormones seen following Roux en Y Gastric Bypass surgery are responsible for some of the beneficial effects seen post-operatively.

Detailed Description

This study is designed to investigate whether chronic elevation of glucagon-like peptide-1 (GLP-1), oxyntomodulin and peptide YY (PYY) in combination is responsible for the majority of the metabolic effects of Roux-en-Y gastric bypass (RYGB) including improved glycaemia, increased energy expenditure, reduced food intake, weight loss, reduced preference for high calorie foods and reduced activation in brain reward areas in response to visual food cues.

Study Timeline

• Study First Submitted: 2013-09-16
• Study First Submitted QC: 2013-09-16
• Study First Posted: 2013-09-19
• Study Start: 2013-10
• Status Verified: 2021-04
• Last Update Submitted: 2021-04-16
• Last Update Posted: 2021-04-20
• Primary Completion: 2028-10-31
• Study Completion: 2028-10-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 190

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Weight loss	Baseline - 4 weeks	Weight loss as measured at baseline compared to 4 weeks after infusion or diet

Secondary Outcome Measures

Name	Time	Method
Glycaemia	Baseline - 4 weeks	As assessed by change in fructosamine and HbA1c levels

Trial Locations

Locations (1)

NIHR/Wellcome Trust Imperial CRF, Hammersmith Hospital; 🇬🇧 London, Greater London, United Kingdom