Investigating the effects of cardio and non-cardio exercise on adults with Attention Deficit Hyperactivity Disorder (ADHD)

Not Applicable

Completed

• Conditions: Attention Deficit Hyperactivity Disorder (ADHD); Mental and Behavioural Disorders; Disturbance of activity and attention

• Registration Number: ISRCTN39271564
• Lead Sponsor: King's College London

Brief Summary

2023 Results article in https://doi.org/10.3390/bs13020129 (added 28/04/2023)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-05-11
• Study Completion: 2022-07-31
• Last Update Posted: 4 September 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 159

Inclusion Criteria

1. Adults aged 18-35 years
2. Fit enough to undertake cardio or non-cardio exercise for 12 minutes
3. Free from any physical, neurological or psychiatric conditions (besides Attention Deficit Hyperactivity Disorder for the patient groups) and learning disorders/disabilities

Participants will fall into one of the following categories in order to be eligible for the study:
1. No current or previous diagnosis of ADHD
2. Current diagnosis of ADHD but not currently receiving any drug treatment for the condition (and have not done so for 6 months)
3. Current diagnosis of ADHD and currently receiving psychostimulant drug treatment for the condition.

Exclusion Criteria

1. Diagnosis of a psychiatric or neurological disorder
2. Learning disability
3. Currently pregnant or breastfeeding
4. Medication adherence <70%
5. Currently receiving non-stimulant medication for ADHD
6. Not fit enough to safely sustain physical activity for 12 minutes
7. Blood pressure > 140/90mmHg on the day of the lab visit

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Attention measured using the computerised Test of Variable of Attention (TOVA) task (omission errors, accuracy, reaction time) before exercise and after exercise during the single two-hour testing session required<br>2. Motor impulsivity measured using the computerised Test of Variable of Attention (TOVA) task (commission errors) before exercise and after exercise during the single two-hour testing session required<br>3. Temporal impulsivity measured using the computerised Delay Discounting Task (indifference point, discounting function) before exercise and after exercise during the single two-hour testing session required<br>4. Cognitive impulsivity measured using the computerised Iowa Gambling Task (proportion of risky decisions) before exercise and after exercise during the single two-hour testing session required<br>5. Hyperactivity measured through actiography (movement in non-dominant wrist) before exercise and after exercise during the single two-hour testing session required

Secondary Outcome Measures

Name	Time	Method
Associative reward learning measured using a computerised Pavlovian conditioning task during eye tracking (reaction time, gaze position) before exercise and after exercise during the single two-hour testing session required