To Compare the Efficacy Of Oral Magnesium And Zinc In Decreasing The Incidence Of Post Operative Sorethroat In Thyroid And Parathyroid Surgeries.

A prevalent complication following orotracheal intubation in patients undergoing general anaesthesia is postoperative sore throat. This is due to the mechanical trauma produced by tracheal intubation, as well as the mucosal irritation, inflammation, and edema caused by endotracheal tube cuff pressure. The goal of this study is to evaluate the effectiveness of oral magnesium and zinc in preventing this complication. These medications have anti-nociception, anti-inflammatory, tissue- healing, and tissue-repair properties. It will be a prospective, randomised, double-blind, placebo- controlled study. Participants will be chosen according to the inclusion criteria after receiving their written consent. Using a computer-generated randomization system, a sealed and coded envelope containing oral zinc, magnesium, or a placebo will be distributed. The code will be kept until the conclusion of the investigation.The dose of Zinc sulphate to be used in this study will be 5mg and Magnesium sulphate will be 10 mg.Placebo will be a sucrose solution matching the same taste,colour, and consistency of Zinc and Magnesium syrups. The patient will be instructed to consume the medication 30 minutes before anaesthesia induction. Standard American Society of Anaesthesiologists monitors will be employed in the operating room. After adequate preoxygenation, the patient will be induced with 2mcg/kg of Fentanyl and 2mg/kg of Propofol, followed by orotracheal intubation after neuromuscular blockade has been achieved with 0.5mg/kg of Atracurium. The anesthesiologist will perform laryngoscopy using Macintosh blades 3 or 4, documenting Grades according to the Cormack and Lehane classification, number of attempts, duration of orotracheal intubation, and/or any complications that may have occurred during the procedure. An appropriate sized endotracheal tube according to the patients gender,weight and age will be used and will be standardizing the cuff pressure to 20-25 cm of H2O in all cases.We will be using ETT size of 6.5/7 for female patients and 7/7.5 for male patients. All intubations will be done by Second year post graduades and above. Isoflurane and intermittent doses of atracurium will be used to maintain anaesthesia. Every 30 minutes, the cuff pressure will be measured and maintained between 20 and 25 cm H2O. During surgery, the use of nonsteroidal anti-inflammatory medications and steroids will be documented. Anesthesiologists will perform oropharyngeal suctioning and then do awake extubation of the patient. On arrival in the recovery room, the patient’s severity of sore throat will be assessed using a standardized four-point pain scale. This assessment is a verbal questionnaire which will be taken at four different time intervals ie 1 hour,4 hour,12 hour,24 hour following extubation.Point 0 indicates no sore throat, 1 indicates a mild sore throat (complains only when questioned), 2 indicates a moderate sore throat (complains even when not questioned), and 3 indicates a severe sore throat (presence of hoarseness or voice change). Anybody with POST score of 3 or more will be treated with NSAIDS like Paracetamol and dexamethasone.They will not be excluded from the study.There will be a record of any adverse effects, such as vomiting, vertigo, metallic taste, or diarrhoea.