Efficacy of intraoperative magnesium and vitamin C in the reduction of severity of pain in immediate postoperative period

All patients will be subjected to the pre-anaesthetic assessment prior to enrollment in the study. Their detailed medical and surgical history will be taken along with any previous anaesthetic exposure with its outcome. A thorough airway, systemic examination will also be done. All patients scheduled for surgery will be kept fasting for at least 6 hours prior to surgery. Randomization will be done by using computer generated numbers into three groups; Group 1 study group (n=30)- patients receiving intravenous vitamin C 3 grams in 100 ml NS, Group II study group (n=30)- patients receiving intravenous magnesium sulphate 2 grams in 100 ml NS, Group III control group (n=30) - patients receiving normal saline. The study drug will be prepared and administered by anaesthesia resident who is not further involved in study. After extubation, postoperative pain will be assessed using VAS scale (0-10) by anaesthesia resident who is involved in the study. Other observations includes time to request for 1st dose of rescue analgesia (i.v Tramadol 1mg/kg) followed by 0.25 mg/kg every 10 minutes over next 3 hours to reduce VAS to 4, time interval between administration of study drug to time to request for first dose of rescue analgesia, total dose of Tramadol,  side effects.