Effects of neuromuscular blockade on transpulmonary pressure and diaphragm activity in paediatric moderate-to-severe acute respiratory distress syndrome: a pilot study

Completed

Conditions: PARDS
10038716

Registration Number: NL-OMON45389

Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 19

Inclusion Criteria

Informed consent
Age younger than 12 years
Need for mechanical ventilation with tidal volume 5 - 8 mL/kg ideal bodyweight and a mimum PEEP level of 5 cmH2O
Early moderate - to - severe paediatric acute respiratory distress syndrome originating from any cause:
• Acute onset of disease, and
• Oxygenation index > 12, and
• One or more (bilateral) infiltrates on chest radiograph, and
• No evidence of left ventricular failure or fluid overload, and
• Within the first 48 hours of diagnosis of PARDS
Indication for continuous infusion of NMBAs at discretion of the attending physician

Exclusion Criteria

No informed consent
Continuous administration of neuromuscular blockade prior at the time of meeting the criteria for PARDS
Chronic respiratory failure on home ventilation
Intracranial hypertension
Bone marrow transplantation
Immunocompromised patients (congenital or acquired)
Pre-existing pulmonary hypertension
Congenital heart disease with left - to - right shunting
Cyanotic congenital heart disease
Withdrawal of life - sustaining treatment
Prematurity (gestational age less than 44 weeks when assessed for eligibility)
History of congenital neuromuscular disorder

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Transpulmonary pressure</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Haemodynamic profile, respiratory system mechanics, metrics for oxygenation,<br /><br>ventilation and deadspace, and diaphragmatic activity and occurrence of<br /><br>pendelluft</p><br>