Effect of neuromuscular blockade on global and regional lung aeration in mechanically ventilated children - a pilot study
Completed
- Conditions
- Acute lung injury10024967
- Registration Number
- NL-OMON37704
- Lead Sponsor
- niversitair Medisch Centrum Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
• Age between 0 and 12 years
• Need for neuromuscular blockade defined by the attending physician
• Presence of acute lung injury
• weight >= 3 kg
Exclusion Criteria
• No need for neuromuscular blockade
• No acute lung injury
• admitted to the neonatal intensive care unit
• premature birth with gestational age corrected for post-conceptional age less than 40 weeks
• congenital or acquired neuromuscular disorders
• severe traumatic brain injury (i.e. Glasgow Coma Scale < 8)
• congenital or acquired paralysis of the diaphragm
• uncorrected congenital heart disorder
• severe pulmonary hypertension
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Differences in global lung aeration as defined by the center of ventilation<br /><br>before and during use of neuromuscular blockade</p><br>
- Secondary Outcome Measures
Name Time Method <p>Differences in regional lung aeration before and during use of neuromuscular<br /><br>blockade</p><br>