Comparison of effect on muscle paralysis and recovery of rocuronium between anaesthesia with isoflurane or propofol in spine surgery.
Phase 3
Completed
- Conditions
- Health Condition 1: null- Posted for spinal fixation surgery
- Registration Number
- CTRI/2018/04/012919
- Lead Sponsor
- Bangur Institute of Neurosciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Patients with physical status ASA I or II.
2.Patients who have given written consent for taking part in the study.
3.Patients scheduled for spinal instrumentation surgery.
Exclusion Criteria
1.ASA physical status III or IV with compromised renal or liver function or respiratory disease.
2.Patients with major comorbidities like diabetes or hypertension.
3.Patients whose body weight is 30% more or less their ideal body weight.
4.Patients with moderate to severe cardiovascular diseases.
5.Patients those receiving medication known to interact with neuromuscular blocking drugs.
6.Patients having coagulopathies..
7.Patients with allergic diasthesis.
8.Patients with pregnancy or breast feeding.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method recovery time indexTimepoint: The time interval between the recovery of TI from 25%-75%
- Secondary Outcome Measures
Name Time Method a.changes in pulse rate and blood pressure. <br/ ><br>b.Continuous monitoring of heart rate, noninvasive blood pressure (NIBP), capillary blood O2 saturation (SpO2),end tidal CO2(EtCo2), bispectral Index (BIS). <br/ ><br>c.By the use of TOF guard the following variables of neuromuscular block will be obtained for both groups . <br/ ><br>Timepoint: 1.Time taken after administration of rocuronium for intubation to reach TOF 0. <br/ ><br> <br/ ><br>2. Time taken for appearance of T1 in TOF. <br/ ><br> <br/ ><br>3.Clinical duration: Time after injection of last cumulative dose of muscle relaxant until 25%of recovery of TI. <br/ ><br> <br/ ><br> <br/ ><br>4.Recovery index: Time interval during which TI recovered from 25%-75% of control. <br/ ><br>