Effect of deep neuromuscular block and variations in arterial PCO2 on the surgical rating scale, extubation conditions and postoperative conditions following reversal with sugammadex
- Conditions
- niercelcarcinoomprostaatcarcinoom1002765510038365
- Registration Number
- NL-OMON38910
- Lead Sponsor
- eids Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 40
(i) Patients diagnosed with renal or prostatic disease who are will undergo an elective
laparoscopic renal surgical procedure or laparoscopic prostatectomy;
(ii) ASA class I-III
(iii) > 18 years of age;
(iv) Ability to give oral and written informed consent.
(i) Known or suspected neuromuscular disorders impairing neuromuscular function;
(ii) Allergies to muscle relaxants, anesthetics or narcotics;
(iii) A (family) history of malignant hyperthermia;
(iv) Women who are or may be pregnant or are currently breast feeding;
(v) Renal insufficiency, as defined by serum creatinine x 2 of normal, or urine output < 0.5
ml/kg/h for at least 6 h. When available, other indices will be taken into account as well such
as glomerular filtration rate < 60 ml/h and proteinuria (a ratio of 30 mg albumin to 1 g of
creatinine).
(vi) Previous retroperitoneal surgery at the site of the current surgery.
(vii) Body mass index > 35 kg/m2
(viii) Chronic obstructive pulmonary disease GOLD 2-4 or a FEV1 less than 70% predicted or VC less than 70% predicted
(ix) chronic pulmonary disease with altered lung physiology (eg. sarcoidosis, cycstic fibrosis, obstructing pulmonary tumors, previous lung surgery)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>To study the surgical conditions in patients undergoing laparoscopic renal or<br /><br>prostate surgery during low and normal arterial PCO2 levels as assessed by the<br /><br>surgical rating scale.</p><br>
- Secondary Outcome Measures
Name Time Method <p>To assess the relation between scoring of surgical conditions by the surgeon<br /><br>and video assisted scoring of surgical conditions.<br /><br>To study the hemodynamic conditions during low arterial CO2 concentration (3.5<br /><br>kPa or 26.3 mmHg) versus normal arterial CO2 concentration (6.5-7.0 kPa or<br /><br>48.8-52.5 mmHg )<br /><br>To assess respiratory function, pain, nausea/vomiting postoperative following<br /><br>anesthesia maintained at low or normal arterial CO2 concentration<br /><br>To assess whether a deep neuromuscular block (PTC 1-2) combined with induction<br /><br>of relative hypocapnia (PaCO2 3.5 kPa or 26.3 mmHg) and reversal with<br /><br>sugammadex (4 mg/kg) will result in extubation within 5-min following reversal<br /><br>and excellent postoperative respiratory conditions.</p><br>